T1D Risk

300K people are at increased risk of clinical T1D1

People at risk icon

There are many
patients with
presymptomatic T1D

More than 300,000 people in the United States are in the presymptomatic stages of type 1 diabetes. Beta-cell destruction begins months to years before the onset of T1D symptoms; those at increased risk may not be aware.1-3

The lifetime risk of developing T1D is 15x higher than the general population for any first-degree relatives of current T1D patients4-6

Type 1 diabetes familial risk graphic

If a father has T1D, the child's risk is

1 in17

Type 1 diabetes familial risk graphic

If a mother has T1D, the child's risk is

1 in25*

Type 1 diabetes familial risk graphic

If both parents have T1D, the child's risk is

1 in10

*If the child was born before mother turns 25 years old; if child was born after 25, risk is 1 in 100.

A child’s risk is doubled if a parent developed T1D before age 11.6

Knowing what to look for and how T1D progresses in patients is the first step in the future of care

1. Ward K, Pan C, Shinde M, Rievathavorn J, Hedge S, Gaebler JA; JDRF. Modeling the total economic value of novel type 1 diabetes (T1D) therapeutic concepts. Published January 2020. Accessed April 22, 2020. https://t1dfund.org/wp-content/uploads/2020/02/Health-Advances-T1D-Concept-Value-White-Paper-2020.pdf.

2. Herold KC, Bundy BN, Long SA, et al; Type 1 Diabetes TrialNet Study Group. An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes. N Engl J Med. 2019;381(7):603-613.

3. Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk progression to diabetes in children. JAMA. 2013;309(23):2473-2479.

4. Couper JJ, Haller MJ, Greenbaum CJ, et al. ISPAD Clinical Practice Consensus Guidelines 2018: stages of type 1 diabetes in children and adolescents. Pediatr Diabetes. 2018;19(suppl 27):20-27.

5. Insel RA, Dunne JL, Atkinson MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care. 2015;38(10):1964-1974.

6. American Diabetes Association. Learn the genetics of diabetes. Accessed September 3, 2020. https://www.diabetes.org/diabetes/genetics-diabetes.